能力的油性配方药物输送到肠道阴谋

文摘

定期和脂质生产在生产大量的详细的学术兴趣和现代口头指导不足水溶剂的药物。尽管如此,令人失望的是没有多少的业务实例lipid-based测量一次“特殊情况”的环孢菌素和脂质可溶解的营养被禁止的想法。可能部分解释背后的无助的业务描述lipid-based口语部分结构结合界面和物理科学的错综复杂的脂质(在各种结构的整体),测试坚硬和组装与创业有关的问题,一些无效地水溶剂药物的偿付能力限制油脂的溶剂、pre-absorptive胃肠道(GI)处理预计大量的脂质,缺乏信息的真正发生codirected药物/脂质在胃肠道管腔内,以及缺乏先见之明体外和体内试验系统。有序的探索性工作需要改善信息基础与利用的交通工具框架。

关键字

调药的;制药配方。

描述

不管上面的约束,脂质提供潜在的本质上升级口服药物摄入许多计划完全空缺有待调查。显著影响食物对改善某些不足吸收药物的生物利用度,与发展的影响在很大程度上归因于食物的脂类物质,证明极其有利的工作来说是足够的,未系统地阐述的脂类药物保留。许多药物组织记录证明这些因素影响生物利用度的一部分他们的混合物,有扩大数量的疏水性药物到达发展阶段。相当多的在第一次尝试在强烈的生物结构,提示基础低生物利用度的不祥的状态下的测量方案。构建需要一眼的传输框架还在开始阶段,不敢继续朝着这条路哪里有一个明显的优势。脂质计划无效地水可溶解的药物为口服提供适应性组织安排,一样可以形成凝胶,停赛,乳剂,self-emulsifying框架和纳米乳。从一个可行的高雅的角度来看,lipid-based计划显然是建立结构可以作为一个单元部分填充到固定困难或微妙的明胶。因此,多考虑有关脂类的定义安排,乳液和微乳液pre-concentrates实际上可以设置为稳定,帮助单位部分计划。协同依赖性的理解和管腔内的脂质之间的相互关系处理,药物溶液化需要的脂质处理和由此产生的增溶脂质在胃肠道内腔加工项目。的共同服用药物的脂质同样会影响同化方法的药物。 Albeit most orally controlled ineffectively water solvent mixtures access the fundamental dissemination by means of the gateway blood (when directed with or without lipids), some profoundly lipophilic medications can likewise access the foundational dissemination by means of transport through the intestinal lymphatics. Where lymphatic vehicle adds to oral bioavailability, the decision of coregulated lipid and the qualities of the definition are pivotal to upgrade of medication assimilation. This arrangement of surveys will endeavor to give a structure in which the significant parts of GI physiology, the selection of lipids and pertinent definition ascribes are incorporated to empower a depiction also, appraisal of the capability of lipid-based details. A few viewpoints will be offered as to implies by which the plan and assessment of lipidbased portion structures may turn out to be less phenomenological than it already has been. A significant issue is the part of lipolysis on the exhibition of conveyance frameworks and the subsequent destiny of the medication, which could incorporate take-up into the lymphatic framework. Openings exist for misuse of the cycle of lipolysis to upgrade bioavailability; potential which has not yet been tapped in an orderly way. Lipid frameworks additionally offer a methods for shielding peptide and protein drugs from the antagonistic climate of the gut. The drug business generally has a guarantee to the strong state, however the accomplishment of Sandoz's cyclosporin items have brought issues to light of the benefits of slick frameworks what's more, this field can anticipate a time of restored interest, all things considered.