维拉帕米在身体和维拉帕米的作用机制

文摘

维拉帕米是用来治疗高血重量和控制心绞痛,速释片太利用单独或与其他的解决方案,以避免和治疗不可预知的心跳。维拉帕米在一个教训的药物称为钙通道阻滞剂。它通过解除血管心也不应该泵一样困难。它也可以用于预防偏头痛和集群头痛[1]。也增加对心脏的血液和氧气供应和温和派电气动作控制心率心脏内。高血压时体重可能是一个常见的条件和不及时治疗,会导致伤害大脑,心脏,血管,肾脏和身体的其他部位。伤害这些器官可能导致心脏感染,心脏攻击,心中失望,中风、肾脏失望,不幸的视野,和其他方面的问题。除了服用药物,生活方式的改变也会提供帮助控制你的血液的体重。这些变化将吃瘦身moo的脂肪和盐,保持一个良好的体重,在轻微的锻炼。异搏定之际,一个平板电脑,一个延长释放(长效)平板电脑,和一个延长释放(长效)胶囊需要用嘴。 The normal tablet is as a rule taken three to four times a day. The extended-release tablets and capsules are ordinarily taken once or twice a day. Take verapamil at around the same time each day. Tentative evidence supports the use of verapamil topically to treat plantar fibromatosis [2]. Certain verapamil products should be taken within the morning and others at sleep time. Inquire your doctor what the leading time is for you to require your medication. Follow the headings on your medicine name carefully, and ask your specialist or drug specialist to clarify any portion you are doing not get it. Take verapamil precisely as coordinated. Don't take more or less of it or take it more regularly than endorsed by your specialist. Verapamil hinders L-type calcium channels by authoritative to a particular zone of their alpha-1 subunit,14Cav1.2, which is profoundly communicated on L-type calcium channels in vascular smooth muscle and myocardial tissue where these channels are mindful for the control of fringe vascular resistance and heart contractility.10 Calcium deluge through these channels permits for the proliferation of activity possibilities fundamental for the compression of muscle tissue and the heart's electrical pacemaker movement. Along with other calcium channel blockers, verapamil is known to induce gingival enlargement [3].Verapamil ties to these channels in a voltage- and frequency-dependent way, meaning partiality is expanded 1) as vascular smooth muscle film potential is decreased, with intemperate depolarizing stimulus. Verapamil's instrument of activity within the treatment of angina and hypertension is likely due to the instrument depicted over. As CGRP-release is controlled by voltage-gated calcium channels [4]. Hindrance of calcium convergence anticipates the compression of vascular smooth muscle, causing relaxation/dilation of blood vessels all through the fringe circulation - this brings down systemic vascular resistance and hence blood weight. This decrease in vascular resistance moreover diminishes the drive against which the heart must thrust, diminishing myocardial vitality utilization and oxygen necessities and in this way lightening angina.Such effect was not documented in another study with ponies [5].Electrical action through the AV hub is dependable for deciding heart rate, and this movement is subordinate upon calcium deluge through L-type calcium channels. By hindering these channels and diminishing the convergence of calcium, verapamil drags out the headstrong period of the AV hub and moderates conduction, in this manner abating and controlling the heart rate in patients with arrhythmia. Verapamil inhibits the ATP-binding cassette (ABC) transporter family of proteins found in stem cells and has been used to study cancer stem cells (CSC) within head and neck squamous cell carcinomas [5].

引用

1。Tfelt-Hansen PC和詹森RH。丛集性头痛的管理。中枢神经系统药物。2012;26 (7):571 - 80。

2。约瑟夫RY et al . 2018。足底纤维瘤病的病因、评估和管理。骨科研究和评论。201雷竞技网页版8;雷竞技苹果下载11:1 - 7。

3所示。斯蒂尔RM, et al .钙antagonist-induced牙龈增生。内科医学年鉴》1994年;120 (8):663 - 4。

4所示。彼得森,et al。维拉帕米和丛集性头痛:还是一个谜。叙述的疗效、机制和观点。Headache.2009;59 (8):1198 - 1211。

5。巴克斯特通用、et al .失败的钙通道封锁,以防止腹腔粘连的矮种马。兽医Surgery.1993;22 (6):496 - 500。6。小君,et al .表征一边种群HNSCC:也可以成为鉴别药物抵抗和药物异常高度侵袭性,Wnt信号”。PLOS ONE。2010;5 (7):e11456。