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9那国际会议在慢性阻塞性肺病和肺,系统性和吸入类固醇的疗效和临床结果communityacquired肺炎患者

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社区获得性肺炎(CAP)是一个顶尖的全球发病率和死亡率的主要原因。帽也成为第六个成年人总体死亡率的最普遍原因。糖皮质激素被认为是最有效的抗炎药和生理原因他们使用患者的感染。其功效治疗帽仍然是有争议的。研究的目标是评估系统的有效性和临床结果和患者吸入类固醇治疗社区获得性肺炎。方法:我们使用四个数据库文献检索过程,酒吧地中海,EBSCO,职业探索和科学直接选定的文章都是那些治疗研究与相关临床问题和会见了容斥标准? ? ?。关键的评估是由评估其有效性,重要性,基于牛津有时医学中心2011年的适用性。结果:三个群组研究文章检索功能。两项研究进行系统性的类固醇治疗的研究进行的其他吸入类固醇。两个三篇文章表明类固醇治疗是降低死亡率和较短的临床稳定。结论:我们建议类固醇治疗,系统性和吸入类固醇帮助加速临床恢复,防止肺炎相关性并发症,降低死亡率,减少机械通气时间和住院时间。社区获得性肺炎(CAP)是一个在每一个在世界范围内的发病率和死亡率的主要原因[1]。 In developing countries, CAP becomes the sixth most frequent explanation for general mortality in adults. In 2004, approximately 10% of adult mortality in geographic region is caused by a tract infection, mainly by a lower tract infection [2]. In Indonesia, CAP is that the favored explanation for mortality in children and also the sixth mortality in adults. supported Riskesdas (Indonesian Basic Health Research) in 2013, both the incidence and prevalence of pneumonia in Indonesia are 1.8% and 4.5% [3]. Despite notable advances in etiologic research, antimicrobial therapy, and supportive measurement, mortality in these patients remains 30% to 50% [2,4]. Therefore, additional potential approaches are needed to get better ends up in severe CAP. Recent studies found that the extent of proinflammatory cytokines like interleukin (IL) -6, IL-8, IL-10, IL-1β, tumor necrosis factor alpha and interferon gamma increased significantly in patients with severe CAP and was correlated with NAC severity. and results. Corticosteroids are known to be the foremost powerful inflammatory inhibitors. They inhibit the expression of proinflammatory cytokines. The immunomodulatory and anti inflammatory pharmacodynamic profile is that the physiological reason for its use in patients with CAP. Corticosteroid therapy is usually used as a treatment for chronic obstructive pulmonary disease (COPD). Its role within the treatment of CAP remains controversial. In some clinical trials, corticosteroid therapy in patients with CAP is thought to be effective in reducing clinical stability time and length of hospital stay. Other trials showed that steroid therapy correlates with a lower fatality rate in patients with severe CAP because it can reduce the excessive inflammatory response within the airways [2,5]. However, an outsized observational study found that corticosteroids had a possible survival advantage in patients with septic shock, complicating CAP [5]. Therefore, the findings showing that corticosteroids reduce mortality could also be thanks to over-inclusion of patients with septic shock or with other conditions known to profit from corticosteroid treatment, including COPD and asthma [6]. Additionally, this study aims to assess the efficacy and clinical outcomes of corticosteroid therapy, both systemic and inhaled, in patients with community-acquired pneumonia. Fahreza Akbar Siregar

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