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包衣微丸片剂中关键配方变量的研究进展

摘要

一对夫妇的单位管理解放剂量类型提供不同的兴趣点超过他们的单一单位伙伴。这些焦点的一个包裹被确定为统一占用的多颗粒的时期胃肠道。虽然有盖的颗粒也会被塞进硬明胶片，但药丸法是理想的方法，因为它有很多优点。尽管如此，有盖颗粒的压缩是一项具有挑战性的任务，需要精简多个配方和程序变量。关键系统变量包括球团的结构、孔隙度、形状和厚度;聚合物涂层的分类与措施;片剂的性质、尺寸和数量。球芯应该是强大的，具有一定程度的柔韧性。它必须极具渗透性，体积小，形式不可预知。获得延迟无负担的基本厚度过去被认为是在2.4和2.8/cm3左右。 Acrylic polymer movies are blender and more appropriate for the covering of pellets to be compressed into tablets. Thicker coatings offer higher imperviousness to frictional powers. Dissolvable built up coatings are bandier and have a greater measure of mechanical soundness than the fluid established ones. The tableting excipients should have cushioning property. They will have to now not be enormously one-of-a-kind in dimension and density from these of the pellet cores in order to hinder segregation. Addition of 30%-60% of tableting excipients is quintessential to avert any harm to the polymer coat and to retain its useful property.

罗山库马尔。B, Nikitha。我

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