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乙醇提取物的抗炎作用Feretia Apodanthera Delile根树皮及其分数和其生物活性成分的识别

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最近的研究使用标准的炎症模型提供了证据表明Feretia apodanthera具有强大的抗炎活动。Feretia apodanthera德尔。使用传统治疗师在世界的某些部分尼日利亚治疗感染性伤口和伤口愈合等通过生化介质与急性炎症有关。在这个研究活性成分的抗炎效果负责Feretia apodanthera,从家庭茜草科植物,是确定。植物的根是来自它的自然栖息地;树皮被刮出,均质和乙醇粗根树皮提取制备。半数致死量(LD50)确定乙醇提取及其对提取得到的分数是薄层和柱层析法。分数的乙醇提取物的抗炎活性测定采用角叉菜胶诱导对白鼠模型的后爪水肿。最有效的乙醇分数进行分析利用红外光谱和全球大气环流模型来确定其生物活性成分。乙醇提取的致命剂量(LD50)被发现超过5000毫克/公斤体重显示相对安全; nine column chromatography fractions were obtained from the extract. Of all the fractions, 5, 8 and 9 were found to be most effective against carrageenan induced edema. The FTIR analysis in the most effective fractions showed the presence of functional groups possessed by ketones, carboxylic acids, alkanes, amines, ethers, ethenes and aromatic groups. The GCMS analysis of the fractions showed the presence of 9-Octadecenoic acid methyl esters and its derivatives as well as other compounds that are of anti-inflammatory effect such as corticosteroids and tetracosanol.

Oluwayinka Olufunmilayo Owolabi,多加Bolanle詹姆斯,威廉•Chintem特有的Okoro

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