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生物聚合物国会2018年:设计的生物聚合物制成的药物输送系统(DDS)控制孔隙度和获取所需的释放动力学-琼娜M R Curto贝拉大学内部

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药物输送系统的设计(DDS)由纤维素构建块在纳米和微尺度是获得结构所需的孔隙度,因此控制释放的分子动力学。DDS是运输治疗分子双氯芬酸,这是一种非常有效的非甾体类抗炎药但重要的诱发胃粘膜在长期治疗的副作用。目标是开发一种生物相容性聚合物系统保留药物,避免其释放酸性胃pH值,并释放它在碱性十二指肠博士在实验和计算设计基于几种纤维素材料使用计划:羧甲基纤维素(CMC), nanofibrillated纤维素(NFC)和微观有原纤维的纤维素(MFC)有不同的尺寸和功能键组。使用SEM图像结构特征做了分析和孔隙优化是使用计算机模拟进行验证。结果表明,可以获得DDS具有不同孔隙尺寸和更好的选择组合。nanofibrillated纤维素和microfibrillated被用来形成一个三维多孔网络和中央军委是用来控制哦,成键和水的亲和力。优化的三维孔隙度、孔隙尺寸和分布是行列式获得结构得以保留de药物和释放它在碱性博士创新DDS形式生物聚合物已经开发出来,以避免双氯芬酸在胃里释放,防止相关的副作用。计算仿真证明是一个有用的工具来预测孔隙度对不同纳米和微有原纤维的纤维素纤维材料的组合。方法用于设计这些纤维多孔材料可以用在其他的形成多孔材料制成的高分子结构单元的组装生物聚合物是生物体。他们是由天然聚合物。 Biopolymers contain monomer units which are covalently linked to form larger structures. There are three main classes of biopolymers polynucleotides, polypeptides and polysaccharides. More often, polynucleotides, such as RNA and DNA, are composed of 13 or more nucleotide monomers composed of long polymers. The last class, polysaccharides, are often structures of linear bonded polymeric carbohydrates and some examples include cellulose and alginate. There are a number of biophysical techniques for determining sequence information. The protein sequence can be determined by Edman degradation, in which the N-terminal residues are hydrolyzed from the chain by one, derivatized, and then identified. Mass spectrometer techniques can also be used. The nucleic acid sequence can be determined by gel electrophoresis and capillary electrophoresis. Finally, the mechanical properties of these biopolymers can often be further measured using optical tweezers or atomic force microscopy. Dual polarization interferometry can be used to measure the changes in conformation or self-assembly of these materials when they are stimulated by pH, temperature. Drug release has been an important topic in the field of drug delivery for many years. With advances in material design and engineering, new materials have increased complexity and additional functions have been developed in drug delivery devices and systems. Natural and synthetic macromolecules are widely used in controlled release drugs to maximize bioeffectiveness, facilitate clinical applicability, and improve quality of life. "Drug release" refers to the process by which drug solutes migrate to the initial position of the polymer system versus the outer surface of the polymer and then to the release medium. Ceaseus is seemingly simple and is influenced by a number of complex factors such as the solubility of the physicochemical properties, and the material properties of the structural system. These factors include the release environment and possible interactions. The rate of release depends on the morphology of the particles, the specific surface and the porosity of the surface. A current trend in the field of controlled drug administration is the development of multi-component material systems with various physicochemical properties. For example, the crosslinked and stable PEG matrices and biodegradable labile gelatin macromolecules composed of semi-interpenetrating networks are subsequently determined by several factors and can be described by a single mathematical model.

琼娜M R Curto

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