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根除幽门螺杆菌的治疗效果和一些抗氧化剂对溃疡愈合率患者幽门螺杆菌pylori-associated十二指肠溃疡。

文摘

本研究的目的是评估在幽门螺杆菌感染内源性抗氧化防御系统的状态使用内窥镜诊断慢性十二指肠溃疡患者通过某些氧化应激生物标记的评估。这些生物标记即等离子体malodialdehyde (MDA)和血液活动的超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GPx)将评估之前和之后的管理组胺H2拮抗剂nizatidine单独或与维生素E(α-tocopherol)或硫辛酸(α-lipoic酸)或两者的结合。这些生物标志物也评估之前和之后政府根除幽门螺杆菌治疗。抗氧化剂和H的效果。幽门螺杆菌根除治疗溃疡愈合率调查。此外,H的功效。根除幽门通过结合使用nizatidine大环内脂类抗菌素克拉霉素和阿莫西林也评估紧密结合溃疡愈合。H。感染十二指肠溃疡病人受到大量氧化应激所反映的明显降低红血球的GPx和SOD活动和血浆MDA水平的高度。治疗H。pylori-infected duodenal ulcer patients with nizatidine alone failed to produce any significant change in any of the measured oxidative stress biomarkers. Treatment with nizatidine in combination with either vitamin E, thioctic acid or a combination of both resulted in a significant increase in erythrocytic GPx and SOD activities and a significant decrease in plasma MDA level. Some post-treatment values of certain oxidative stress biomarkers (e.g. MDA, GPx and SOD) were not significantly different from normal control values following oral treatment with H.pylori eradication therapy or nizatidine combinations with either vitamin E, thioctic acid or a combination of both. The use of triple H.pylori eradication therapy consisting of nizatidine (300mg once daily for 6-weeks), clarithromycin (500mg twice daily for 10 days) and amoxicillin (1000mg twice daily for 10 days) resulted in 100% eradication rate of the organism in H.pylori-infected duodenal ulcer patients. Attenuation of oxidative stress in H.pylori-infected peptic ulcer patients either by combined nizatidine/antioxidant treatment or by H.pylori eradication therapy was associated with higher ulcer healing rates (on a percentage basis) as compared with patients treated with nizatidine alone. In patients receiving H.pylori eradication therapy, the ulcer healing rate was 100% compared to 60% in those treated with nizatidine alone and 86.67%, 73.34% and 93.34% in patients treated with nizatidine in combination with either vitamin E, thioctic acid or a combination of both respectively.

艾哈迈德·M·阿里

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