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表皮生长因子受体和ki - 67在成釉细胞瘤免疫组织化学表达

文摘

成釉细胞瘤是最常见的良性肿瘤的下颌牙原性的肿瘤的发展。然而,手术后复发的高速率报道。表皮生长因子受体(EGFR)已被证明的重要性某些类型的肿瘤的起源和行为像固体多腔的造釉细胞瘤。ki - 67是一个分子可以很容易地发现在增殖细胞中为了了解肿瘤细胞内的速度增长。本研究的目的是研究表皮生长因子受体的表达率和ki - 67澄清他们的角色在生物行为的病变。口腔病理学部门在大马士革大学牙科学院收到25的造釉细胞瘤标本时间2005年10月到2010年10月。这些标本进行免疫组织化学与抗EGFR单克隆抗体和抗ki - 67。本研究将这些与10正常口腔味蕾被流产胎儿的年龄7个月按照有关法律。结果表明,病人的样本的平均年龄是43.2岁。影响女性倾向于观察(影响女性患者的72%)。 Observed tumor types were as follows: 12 follicle type, 7 plexiform type, 6 of them were admixed. EGFR was found to be highly expressed in 19 specimens, mildly expressed in 5 specimens, and negative in only one specimen. Ki-67 expression was close to that of EGFR. There was a statistically significant relationship between the expression of the EGFR and Ki-67 monoclonal antibodies and the different patterns of the tumor islands (p<0.01). In conclusion, ameloblastoma is a positive EGFR tumor. There was a high Ki-67 index, which is associated with a high proliferation rate, which may indicate a high recurrence rate as proven by other studies

杜尼娅W Sabea

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