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2019年欧元生药学:黄连木乳香树的生物活性化合物对人类health-Djebbar Atmani-UniversitA©德贝贾亚

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文摘药用植物被认为是一个重要的来源的发现潜在的抗氧化,抗癌,抗炎,抗糖尿病的物质。本研究旨在调查抗炎,治疗糖尿病药和抗癌潜力黄连木乳香树(Anacardiaceous)提取,以及活性化合物的识别,使用适当的方法。口服原油提取的树叶和水果(100和200毫克/公斤)显著降低carrageenan-induced老鼠爪子水肿与标准药物双氯芬酸(50毫克/公斤)。此外,黄连木乳香树叶提取物是有效地降低血清水平的IL-1I²相比乙酰水杨酸。血糖水平恢复到正常的价值观,对浓度(50和125毫克/公斤)测试,符合体外抗糖尿病的效果。p .乳香树提取物也被发现明显细胞毒性在黑色素瘤B16F10细胞线,显示出很好的anti-hyperuricemic活动。植物化学的分析表明存在大量的类黄酮,单宁和酚类物质提取的植物,如没食子酸、myricetin-rhamnoside,槲皮素3-O-rhamnoside,协同酸和鞣花酸,可以观察到的活动负责。获得的结果表明,黄连木乳香树提取物表现出强烈的生物效应和可能是一个候选药物的发展,可用于治疗对inflammatory-related紊乱。黄连木乳香树瀑布。(家庭- anacardiaceous),俗称乳香树或mastagi,被用于传统药物体系长期以来治疗各种各样的疾病。 Its various parts contain a variety of chemical constituents which are medicinally important such as resin, essential oil, gallic acid, anthocyanin’s and flavonol glycosides, nortriterpenoids, α-tocopherol and arabino-galactan proteins. Pistacia lentiscus L. belongs to Pistacia genus of Anacardiaceae family of Sapindales section of the plant kingdom. Other important members of the same family are Pistacia atlantica (hackberry), Pistacia terebinthus (turpentine tree) and Pistacia vera (pistachio). Mastic resin has been used as raw material from the leaves and fruits as a drug in many countries since the very old times. It is seen in the literature that mastic is widely used in medicine and pharmacy. It is used in dyspepsia treatment, against anti-atherogenic microbes, as an anti-mutagen, anti-oxidant, anti-fungal, against liver fattening, to treat wounds, as a hypotensive, antiarthritis, and anti-gout Some studies report positive outcomes by mastic oil in prevention and treatment of some types of cancer, as well as treatments for peptic ulcer and helicobacter (Chadzopulu et al., 2011) Mastic tree may be economically utilized for an average of 50 years. It is important to note that, a mutant p53 will not bind to DNA in an effective manner, and, as a result, the p21 protein will not be available to act as the "stop signal" for cell division. 50% ethanolic extract of Chios Mastic Gum (CMG) of Pistacia lentiscus was found to be working like p53 in inhibiting proliferation and inducing death of HCT116 human colon cancer cells in vitro, by exerting concentration dependent apoptosis through direct or indirect induction of cell arrest at G1phase followed by DNA damage. The essential oil and gum from the plant have been widely used as food and beverage flavoring additives and traditional medicines in the Mediterranean area since ancient times. Pistacia species have widely used in food industries, for example in adherent production, in alcoholic and non-alcoholic refreshments, in cosmetics as filling material ingredient in dentistry and in toothpaste production. Note: This work is partially presented in 7th European conference on Pharmacognosy, Medicinal Plants and Natural Products December 02-03, 2019 held at Paris, France. Djebbar Atmani

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