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HPV-DNA检测在宫颈癌前病变和癌前病变检测中的应用价值。

摘要

宫颈的知识瘤形成都是由人类乳头状瘤病毒(HPV)感染导致评估其在宫颈瘤变筛查中的作用。本研究旨在评估HPV-DNA检测在宫颈癌前病变和癌性病变诊断中的准确性。共有115名符合条件的妇女被纳入本研究。在记录相关资料后，用眼镜对宫颈进行肉眼检查。同时进行Paps涂片采集和VIA检测。对筛检阳性的患者进行阴道镜检查。此外，宫颈严重异常甚至筛查阴性的受试者也被推荐进行阴道镜检查。从转诊进行阴道镜检查的患者中提取HPV DNA样本，并在同一患者中进行活检。组织学诊断为CIN或更严重的病变为真阳性。研究结果显示，VIA检测参数敏感性为94.11%，特异性为57.57%，阳性预测值为12.20%，阴性预测值为99.70%。 The test parameters for Pap smear were sensitivity of 64.71%, specificity of 94.29%, positive predictive value of 51.70% and negative predictive value of 99.80%. The test parameters for HPV DNA test were sensitivity of 82.35% and specificity of 84.85%, positive predictive value of 73.68% and negative predictive value of 90.32%. VIA and HPV-DNA tests detected all cases of high grade lesions (CIN II & III) and carcinoma. This study was that VIA is superior to Pap smear cytology and HPV-DNA test in sensitivity, that is VIA can more accurately identify the CIN/ cancer patients, On the other and Pap smear is superior to VIA and HPV-DNA test in specificity that it can more accurately identify the truly well people and HPV-DNA has strong association in high grade lesions of the cervix.

Nahid Yusuf, M Ahmed Ali, Md Latifur Rahman, Hasina Akther, Jahan Ara Khanam和Md Nazrul Islam Mondal

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