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硫酸特布他林快溶片的研究进展

摘要

收稿日期:10-07-2016修回日期:12-08-2016收稿日期:18-08-2016 *通讯作者:Shakeena G，印度安得拉邦(Andhra Pradesh) Ponguturu, Koyyalagudem, West Godavari-534312, Green Royal Academy of Pharmaceutical Education & Sciences，药物分析与质量保证系，Tel:9949581690。电子邮件:(电子邮件保护)关键词:快溶片，微晶纤维素，口服途径，淀粉乙醇酸钠，硫酸特布他林硫酸特布他林用于治疗呼吸系统疾病和呼吸系统疾病。特布他林属于一种肾上腺素能激动剂支气管扩张剂。它是一种β2阻滞剂，用于治疗心血管疾病，如高血压，心脏病，以及定期复发的紊乱，心肌梗死和有目的的心脏疾病。以结晶纤维素和淀粉乙醇酸钠为原料，制备了硫酸特布他林快溶片。硫酸特布他林半衰期为2-3小时，口服利用率为38±14%，从血浆中迅速消除，微晶纤维素和淀粉乙醇酸钠在间隔8-10分钟内分别排出95.2%和96.8%的药物。该片剂用于典型片剂吞咽有问题的患者;需要经常给药，以照顾治疗浓度。药物的快速溶出和吸收可能导致快速起效。快速溶解药物输送系统fddds，快速分解和释放活性成分，不需要水吞咽。口服苦味药物并伴有适当程度的适口性是通过掩盖味道来实现的。 Fast dissolving tablet FDT is employed as super disintegrants which can give immediate disintegration and releases the drug in saliva. Fast dissolving tablets of terbutaline sulfate tablets are ready by the direct compression technique once incorporating with super disintegrants similar to crystalline cellulose and sodium starch glycolate in numerous concentrations. evaluation for prepared tablets were weight variation, thickness, hardness, friability, wetting time, drug content, water absorption quantitative relation, in vitro dispersion time, in vitro disintegration time and in vitro drug release..

Gadde Shakeena

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