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生物聚合物国会2018:Gelatin-based electro-responsive水凝胶的生物医学应用程序——Neslihan Alemdar -马尔马拉大学

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水凝胶是高分子材料三维、交联、亲水结构及其含水量更有利的使用在组织工程、生物医学和生物技术领域相对于其他合成生物相容性材料由于其多孔结构和软。智能高分子材料是高分子材料的机械和物理变化与外部刺激如pH值、温度、电气,因此他们有广泛的使用在控制药物输送系统,最重要的一个生物医学领域用于治疗疾病,如癌症、慢性疼痛,需要药物控制。明胶或明胶是半透明的,无色,无味的食物成分,来自胶原蛋白的动物的尸体。脆弱的时候当湿干燥和粘性。它也可以称为水解胶原蛋白,胶原蛋白水解产物,明胶水解产物,水解明胶和胶原蛋白肽后发生水解。用作胶凝剂在食品、药物、维生素和药物胶囊,胶卷和纸,和化妆品。明胶是一种不可逆的水解胶原蛋白,水解减少蛋白质纤维小肽;根据变性的物理和化学方法,肽的分子量范围。明胶在明胶甜点;大多数糖果和粘性的棉花糖; and ice cream, dips and yogurt. Cooking for Gelatin comes in the form of powder, granules and leaves. Instant types can be added to foods as; Others must soak granules and leaves in water beforehand. If the raw material used in the product is gelatin derived from bones, dilute acid solutions are used to remove calcium and other salts. Hot water or more solvents can be used to reduce fat content, which should not exceed 1% before the main extraction step. If the raw material of skins and skin; size reduction, washing, removing hair from the hides and degreasing the hydrolysis step for the needles and skins. The extraction is carried out with water or acid solutions at appropriate temperatures. All industrial processes are based on neutral or acidic pH values, but alkaline treatments accelerate conversion, and they also promote degradation processes. Acid extraction conditions are widely used in industry, but with varying degrees of acid varies. H are a three-dimensional crosslinked hydrophilic structure with polymer materials and their water content is a highly porous and flexible structure compared to the fields of tissue, biomedical and biotechnological engineering. Smart polymers are polymeric materials that exhibit mechanical and physical changes with external stimuli such as pH, temperature, electricity, and so on. controlled drug release. Based on this information, we have produced controlled drug administration for gel-sensitive electro-sensitive hydrogels. The hydrogels were obtained by characterizing FT-IR and SEM analyzes. For the release experiments, a model drug was loaded into the hydrogels, then the kinetics of the drug release from the gelatin-based hydrogel were studied under different tension conditions. The results showed that the gelatin-based hydrogel could be a promising electro-sensitive biomaterial for the treatment of cancerous diseases. Hydrogels are crosslinked polymers that are capable of absorbing a large amount of water and solvents in their swollen matrices and providing a sustained distribution of absorbed solutes. The use of various functional biopolymer types as hydrogels in scaffolding materials is not only of great interest but is also an underutilized resource but has been considered as a component for the most potential candidate. hydrogel due to its hydration properties such as swelling and solubility; gelling behavior such as gel formation, texturing, thickening and water binding capacity; and surface behavior such as emulsion and foam formation, stabilization, adhesion and cohesion, protective colloid function and film forming capacity. In addition, its biocompatibility, low toxicity, Antimicrobial activity and biodegradability properties make it possible for diverse biomedical applications. Numerous works have been reported in various scientifically replicated journals and publications in the world which seem to have antimicrobial activity and biodegradability for various biomedical applications.

Neslihan Alemdar

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