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Hydro-Alcoholic提取物的降糖和降血脂药活动Echinochloa Frumentacea链接谷物在四氧嘧啶诱导糖尿病大鼠

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调查hydro-alcoholic提取物的降糖和降血脂药活动Echinochloa frumentacea链接谷物在四氧嘧啶诱导糖尿病大鼠。一剂研究是研究在正常大鼠12小时。口服葡萄糖耐量试验(OGTT)在正常大鼠口服葡萄糖后执行(2 g / kg)和糖尿病诱导大鼠口服葡萄糖后(3 g / kg)。糖尿病是由ALX(120毫克/公斤,i.p)三种不同剂量的HAEF(200、400和600毫克/公斤,订单)的HAEF在实验性糖尿病诱导的大鼠口服药物治疗21天。格列本脲(5毫克/公斤订单。)作为参考标准。空腹血糖水平、体重变化和器官重量、血清白蛋白、尿素、总蛋白、肌酐、总血脂、血红蛋白、谷胱甘肽,SOD和TBARS进行评估。最后的胰腺组织病理学检查。单剂量的研究HAEF正常小鼠表现出显著降低空腹血糖水平与正常相比控制老鼠。口服葡萄糖耐量试验清楚地表明,400毫克/公斤和600毫克/公斤以上HAEF显示显著降低血糖水平。然而,p 200毫克/公斤。o showed little effect. Oral glucose tolerance test in ALX induced diabetic rats 400mg/kg and 600mg/kg p.o. of HAEF shown a significant decrease in the blood glucose levels.. In diabetic rats, treatment with the 400, and 600mg/kg, p.o. showing significant reduction in the fasting blood glucose levels, serum cholesterol, serum triglycerides, LDL-C and VLDL-C levels. A significant escalation was seen in the levels of HDL-C, haemoglobin, body weight and organ weights. Whereas, the anti-oxidant levels TBARS, GSH and SOD levels were improved than the untreated diabetic rats. HAEF have shown significant In-vivo antioxidant property and hypoglycemic and hypolipidemic activity.

Ramu矿Ravirala、Sarita Kotagiri Vrushabendra哲人BM,医生专家P,和史学者公里

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