本研究进行dolutegravir采用固体分散技术。磷酸盐缓冲剂的pH值6.8的λmax dolutegravir被发现是在334海里。纯药物的固体分散优化配方受到红外光谱研究。结果表明,没有药物和辅料之间的交互。的测微的性质的混合dolutegravir实色散对休止角的特点,体积密度,利用密度,卡尔的指数和Hausner的比率。休止角小于280年,卡尔的索引值是10至17岁的预压缩混合批次显示公平的流动性和压缩性。Hausner所有批次的比率小于1.2表明良好的流动性能。不同批次的所有平板电脑的重量差异符合官方要求通过限制自己的体重变化。药片的硬度范围从2到3公斤/平方厘米,易碎性值低于1%,表明平板电脑是紧凑和努力。平板电脑的厚度介于3.1至3.8毫米之间。 All the formulations satisfied the content of the drug as they contained 96%-100% of dolutegravir and good uniformity in drug content was observed. Thus all the physical attributes of the prepared tablets were found to be practically within control limits. The dissolution profile of dolutegravir tablets were compared between solid dispersion tablets. The dolutegravir solid dispersion tablets showed better release in phosphate buffer pH 6.8, in that F2 showed good drug release i.e., 99.89 at 15 minutes. F2 formulation was taken as optimised formulation.
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