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在有机化学:2018 -隔离,结构说明,和叶提取物的生物活性研究Vernonia amygdalina——Muluye Melak Zenebe

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Vernonia amygdalina (VA)是一个热带非洲植物菊科家庭和偶尔栽培的药用用途,其中包括用于治疗腹泻、皮肤伤口,感染发烧乳腺炎和温暖。本研究的目的是隔离并阐明的一些化学成分的结构的叶子Vernonia amygdalina及其生物活性。后,甲醇提取物Vernonia amygdalina重复色谱法导致了隔离不同的化合物,这种化合物(MM-4)之一是部分基于光谱特征的数据(IR、1 h NMR、13 c NMR和部门)和提取物Vernonia amygdalina已被证明有抗菌活性。关键词:Vernonia amygdalina,菊科Vernonia amygdalina菊科(家庭)可能是一个有价值的药用植物,在东部和西部Africa2广泛。称为苦叶,应该作为活跃anti-cancer3,抗菌,抗疟疾和寄生虫agent4。这种植物含有复杂的活性成分,药物是有用的。利用树叶的根源,因此民族医学治疗发烧、打嗝、肾脏问题,和胃discomfort5。茎和根被剥离的树皮被用作chew-sticks许多西非国家喀麦隆、加纳和尼日利亚。的叶子Vernonia amygdalina (VA)是最广泛被绿叶蔬菜等喀麦隆人婚礼、洗礼,圣诞节和生日。药理研究也表明,叶提取物都降糖和降血脂药属性。 Traditional medical practitioners, herbalists, and indigenous healers in West Africa recommend an aqueous AV for his patients. Vernonia amygdalina, a member of the daisy family, may be a small shrub that grows in tropical Africa. V. amygdalina typically grows to a height of 2–5 m (6.6–16.4 ft). The leaves are elliptical and up to twenty cm (7.9 in) long. Its bark is rough.[1] V. amygdalina is usually called Congo Bololo in D. R. Congo, bitter leaf in English due to its bitter taste. African common names include grawa (Amharic), ewuro (Yoruba), etidot (Efik), onugbu (Igbo), ityuna (Tiv), oriwo (Edo), Awɔnwono (Akan), chusar-doki (Hausa), mululuza (Luganda), labwori (Acholi), olusia (Luo), ndoleh (Cameroon) and olubirizi (Lusoga The Tongwe use cold concoctions of this plant as a treatment for malaria, intestinal parasites, diarrhea, and indigestion . for varied African ethnic groups, a concoction of this plant is additionally a prescribed treatment for malarial fever, schistosomiasis, amebic dysentery , and a number of other other intestinal parasites and stomach aches. In pharmacolog, biological activity or pharmacological activity describes the beneficial or harmful effects of living on a drug. When a drug can be a complex chemical mixture, this activity is exerted by the active ingredient of the substance or the pharmacophore but is often modified by the opposite constituents. Among the various properties of chemical compounds, pharmacological / biological activity plays an important role because of its applications in medical applications. However, chemical compounds can have harmful and toxic effects that can prevent their use . Activity is usually dosage-dependent. Further, it's common to possess effects starting from beneficial to adverse for one substance when going from low to high doses. Activity depends critically on fulfillment of the ADME criteria. To be an efficient drug, a compound not only must move against a target, but also possess the acceptable ADME (Absorption, Distribution, Metabolism, and Excretion) properties necessary to form it suitable to be used as a drug. Structure elucidation of the bioactive constituent depends almost exclusively on the appliance of recent instrumental methods, particularly high-field NMR and

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