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2017年化学工业:有机小分子催化剂不对称直接醇醛反应水媒体:绿色化学方法- Kartick C Bhowmick工业应用

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organocatalysis在水媒体是一种最区勘探领域从事倾斜组合。错误的碳碳键形成反应涉及领域的焦点地区希特勒平衡自然混合醇醛反应是无比了。大范围的精明的天然材料,包括脯氨酸及其下属不平衡醇醛反应有效的推动作用。后期,更多考虑已创建organocatalysts倾斜直接醇醛反应在水里,因为它提供了一些非凡的特性,将巨额强大的生命力厚度、表面压力高,疏水可溶解的影响,特别是它是自然慷慨。希特勒的改善平衡organocatalyzed直接醇醛反应的媒体,例如,有点organocatalyst, L-Proline酰肼已经用于直接不平衡的醇醛的反应在室温下不同的酮和芳香醛在接近一些腐蚀性物质。叠加10 mol %增加动力和p-toluenesulphonic腐蚀性物质,利用在这个反应,和伟大的收益率(99%),高的敌人/ syn选择性很大(95:5)和选择性(> 99.9%)可以完成在流体介质。另一个新organocatalyst, 4-hydroxy-L-proline和松香的腐蚀性之间用于醇醛反应一定不好过芳香醛和酮在接近一些腐蚀性物质在水媒体补充道。比较醇醛项目中得到高承压收益率(99%)和高选择性很大的敌人(94%)和选择性(> 99.9%)。堆积的动力是降低至1摩尔%,从本质上讲,醇醛反应被认为是令人难以置信的快速在水中。尽管上述organocatalysts的提高,一些腐蚀性添加物质的影响研究在失败直接醇醛反应催化C2-symmetric organocatalyst水汪汪的媒体。 A progression of profoundly effective organocatalysts have been gotten from normally accessible amino acids for completing enantioselective direct aldol response in both natural and watery medium. The aldol items were acquired in high diastereoselectivities (up to 99:1) and enantioselectivities (up to >99% ee) for a more extensive scope of substrates utilizing 1 mol % of an impetus. The outcomes show that the auxiliary highlights of organocatalysts assume a vital job in getting high optical virtue of aldol adducts in a watery medium. Further, the job of water in expanding the rate and enantioselectivity of the response has been outlined. Additionally, the aldol items have been utilized in the blend of chiral amino alcohols which go about as helpful intermediates for working up complex normal items. research focus on the development of asymmetric organocatalysis for carbon-carbon bond-forming reactions in aqueous media. His research on the development of small organic molecules as organocatalysts for direct aldol reaction impacted significantly in the field of asymmetric organocatalysis. He has developed many optically pure organic molecules which efficiently catalyzed the direct aldol reactions with great yield and selectivity in aqueous media. His newly developed methodology replaced the use of volatile organic solvents and hazardous metal catalysts in asymmetric aldol reactions, thus by contributing enormously towards the development of sustainable organic synthesis kartickb@yahoo.com

Kartick C Bhowmick

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