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Non-metastatic直肠癌:治疗性和进化方面

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摘要:研究目的:评价non-metastatic直肠癌的治疗和进化方面。方法:回顾性研究包括45 non-metastatic直肠癌病人在2010年到2017年之间。中位数年龄为59岁。性别比例为1.36。组织学类型Liberkhunian腺癌在97.8%的情况下。所有的病人评估扩展。84.4%的患者的肿瘤分类T3和T4在13.3%的病人。淋巴结状态是N1、N2和N3在82.2%的情况下。结果:42例患者采用术前化疗的剂量45 Gy电台在25个分数。三个病人术前放疗剂量25 Gy 5的分数。 The chemotherapy used was fufol, in 88.1% of cases. Sixteen (35.6%) patients had radical surgery and 53.3% had anterior resection. Histopathological examination showed a complete response in 13.6% of cases. Lymph node involvement was noted in 32.6% of cases. The surgery was R0 in 84.8% of cases. Adjuvant chemotherapy was given in 46.7% of cases. After an average follow-up of 36 months, 11.1% of patients had locoregional recurrence and 15.6% had metastatic progression. Overall survival was 80% at 3 years and 60% at 5 years. Conclusion : Preoperative radiotherapy with or without chemotherapy provides for our patients with non metastatic rectal cancer survival rates close to those of the literature. Biography : Hanene Ben Salah a professor of medicine, a specialist in radiotherapy in Habib Bourguiba Hospital in Sfax, Tunisia. She has published more than 20 papers. Presenting author details Full name: Hanene Ben Salah Contact number: +201699608777 Poster presentation (Track Name: others) Materials and methods: The MEDLINE, EMBASE and Cochrane Library databases, as well as meeting proceedings from the American Society of Clinical Oncology, were searched for reports of randomised controlled trials and meta-analyses comparing preoperative or postoperative therapy with surgery alone or other preoperative or postoperative therapy for stage II or III rectal cancer. The draft practice guideline and systematic reviews were distributed through a mailed survey to 129 health care providers in Ontario for review. Results: Systematic reviews on preoperative and postoperative therapy for rectal cancer were developed. On the basis of the evidence contained in these reviews, the Gastrointestinal Cancer Disease Site Group drafted recommendations. Of the 33 practitioners who responded to the mailed survey, 97% agreed with the draft recommendations as stated, 88% agreed that the report should be approved as a practice guideline and 94% indicated that they were likely to use the guideline in their own practice. Conclusions: Preoperative chemoradiotherapy is preferred, compared with standard fractionation preoperative radiotherapy alone, to decrease local recurrence. Preoperative chemoradiotherapy is also preferred, compared with a postoperative approach, to decrease local recurrence and adverse effects. For patients with relative contraindications to chemotherapy in the preoperative period, an acceptable alternative is preoperative radiotherapy alone followed by surgery. Patients with resected stage II or III rectal cancer who have not received preoperative radiotherapy should be offered postoperative therapy with concurrent chemoradiotherapy plus fluoropyrimidine-based chemotherapy. This work is presented at International Conference on Gastroenterology and Liver on March 18-19, 2020 at Amsterdam, Netherlands

Hanene本沙拉

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