的下颌骨坏死患者接受长期治疗磷酸盐:发病率和相关特征
简介:磷酸盐(BPs)提供一个众所周知的,有利的治疗作用在骨组织接受这些药物的患者。目的:本研究的目的是将长期治疗与氮磷酸盐ONJBPs(磷酸盐引起的下颌骨坏死),最常见的副作用在下巴。2007年,AAOMS ONJBP的概念定义为“一个暴露的骨头坏死区域嘴里出现了八周与磷酸盐治疗病人在接受长期治疗,谁没有收到头部和颈部放射治疗。”Subsequently in 2009 the AAOMS defined 4 clinical stages (0 to 3) of ONJBPs. Subjects and methods: Between January 2007 and December 2013 25,538 patients were referred to the Department of Maxillo-facial Surgery and Traumatology II of the School of Dentistry, University of Buenos Aires Argentina. All these patients underwent surgical dental treatment and the 1097 patients found to have healing dyscrasias were subsequently divided into three groups. All 1097 patients included in this study underwent semiological systemic clinical, dental, biochemical, histopathological studies as well as densitometry and X-ray imaging. Results: Of the 25,538 patients evaluated, 0.33% were found to have ONJBP. Of the 1097 patients with healing dyscrasias, the incidence of ONJBP was 7.75%. Among the 270 patients who took BPs the incidence of ONJBPs was 31.5%. Clinical studies in Group 1 patients revealed mainly stage 1 and 2 disease. There were no significant differences in CTX levels for either of the two groups evaluated. Conclusion: The results of the present study suggest a significant incidence of ONJBPs, especially when only individuals treated with BPs are included for the calculations. It is also clear that interaction among healthcare professionals is essential, since ONJBPs prevention is better than its treatment.
西尔瓦娜米Picardo *和爱德华多阿尔贝托·雷伊
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