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快速、经济的检测耐药结核病(MDR):利福平耐药性(RMPr)可以替代标记为耐多药结核病?

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成功治疗耐药结核病(mdr - tb)的依赖促使实验室检测耐药。基因型的研究旨在调查效用MTBDRplus(线性探针测定:基因型)耐多药结核病检测和快速经济的快速方法检测耐多药结核病,直接敏感试验(Phenotypic-Direct)评估。进一步还尝试探讨利福平耐药性的重要性(RMPr)作为代理的标志多药耐药性(MDR)肺结核。43痰抗酸杆菌涂片阳性= 1 + &上图)标本构成本研究的材料。RMPr /耐多药检测是由线性探针测定(LPA)和直接的灵敏度(DS),这是与比例进一步评估方法(下午:表型)被认为是黄金标准统计计算。LPA以及DS被发现为检测MDR 100%敏感。LPA结果分析进一步揭示了S531L (rpoB) + S315T1 (kat G)是最常见的突变模式。目前的研究发现RMPr是个好代理的标志识别耐多药菌株。然而,我们回顾性分析基于比例方法包括5年发表的数据显示MDR的比例将从47.54%提高到74.44%,如果我们考虑利福平monoresistance作为MDR的替代标记。本研究发现LPA好快速技术,可以用于快速检测耐多药/ RMPr。直接的敏感性是资源约束的另一个合适的选项设置。 Both the techniques were well comparable with the gold standard proportion method. Larger studies are required to call RMPr as surrogate marker of MDR-TB. LPA is definitely a good tool for rapid detection of MDR provided one has a requisite infrastructure and trained man-power. The results of DS test were really encouraging which made us to think to replace proportion method where a lot of technical expertise required. Larger studies are required to call RMPr as surrogate marker of MDR-TB.

利Sarala Menon Priyanka Kembhavi Nilma Hirani, Wabale Ameeta Joshi

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