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takayasu指出动脉炎患者的回顾性临床研究

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目的:研究临床特征血管造影发现,Takayasu指出动脉炎患者的治疗反应和预后。方法:七十三例Takayasu指出动脉炎住进我们医院2006年1月至2011年8月回顾性评估临床表现,实验室试验,血管造影发现,疾病的治疗反应和预后。结果:男性有20例,53岁女性Takayasu指出动脉炎患者73例,男性对女性的比例是1:3.8。发病的平均年龄(33.9±12.0)岁(哟),和第一次的平均发病年龄的症状是26哟(范围14 - 63哟)。五个病人都不到18哟,和22 40岁以上患者哟。头晕的发生率、倦怠、高血压、弱脉或无脉性血管杂音和不对称的血压存在对比在60%,40%,70%,30%,72%和54%。血管造影结果显示Typea…(36%)我¼Œa型…£(23%)我¼ŒTypea…¤(25%)是常见的,和Typea…¡(1%),Typea…¡b (7%)、a型…¢(8%)都很少见到。Takayasu指出动脉炎的疾病活动应该根据评估水平的升高红细胞沉降率(ESR)、c反应蛋白(CRP),在33%和37%的患者,分别。58例病人接受了不同的血管造影,其中29日接受了支架植入术。十干预(34.5%)restenosed(31.4±11.7%)个月后干预。 Seventy patients (96%) received Aspirin (100mg/d) therapy, three patients (4%) received clopidogrel at a daily dose 75mg, twenty-four of them received glucocorticoids with immunosuppressive agents and 14 patients received glucocorticoids alone. Of patients with intervention, non-intervention and restenosis, there was no difference in mean age (P=0.25), ESR (P=0.47) and CRP (P=0.98); whereas, there was statistically significant difference in mean age (P=0.007), ESR (P=0.044) and CRP (P=0.001), among patients with glucocorticoids and immunosuppressive agents, none of them and alone. Conclusions: Clinical signs and symptoms of patients with Takayasu arteritis (TA) were atypical in the early stage. Physicians should increase awareness to prevent delay diagnosis in TA. Angiography was the gold standard for diagnosis. Sedimentation rate (ESR) and C-reactive protein (CRP) contributed to guide the treatment of patients with TA and evaluate the disease activity.

耿Chao-Fei周、明治沈钱Yi-Hong任*

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