编辑雷竞技app下载苹果版

白细胞介素- 6信号的发展的贡献T辅助免疫反应在慢性阻塞性肺疾病

文摘

(慢性阻塞性肺病)。已经表明,il - 6作用于辅助细胞(CD4 +),因此,影响的形成T辅助(Th)免疫反应,这决定了的病理过程。然而,免疫调节作用的分子基础的il - 6在COPD并没有得到充分的研究。本研究的目的是评估膜受体的表达水平il - 6 (IL-6R / CD126 +)在慢性阻塞性肺病患者CD4 +细胞不同程度的不同类型的免疫反应。方法:研究包括98名稳定的慢性阻塞性肺病患者(34温和,45温和,19严重)和32名健康志愿者。Th免疫反应的类型取决于计算血清细胞因子的浓度之比吗? ? ?肿瘤坏死因子- ?干扰素- ?il - 4 6、-10、-17(美国BD)。细胞因子水平和血液CD4 + CD126 +细胞的数量进行评估通过流式细胞术(血细胞计数器? ? ?BD FACSCanto II ? ? ?美国)。 Findings: Th1 and Th17 immune response were found in stable COPD. The number of CD4+CD126+ cells was increased by 111% (p<0.001) in patients with severe COPD with Th1 immune response compared to healthy persons. The levels of CD4+CD126+ cells was elevated by 47% (p<0.05), 117% (p<0.01) and 286% (p <0.01) in patients with mild-to-severe COPD with Th17 pathway, respectively compared to the control group. Conclusions: Systemic inflammation in stable COPD develops predominantly according to Th1 or Th17 immune response. Increasing the expression level of IL-6R on blood CD4+ cells is a possible mechanism for enhancing the Th17 immune response as COPD progresses. Th1 immune response is characterized by the raised expression of IL-6R on blood CD4+ cells only in patients with severe COPD. It may be associated with the repolarization of this phenotype towards Th17 as the disease progresses. Recent Publications 1. Vitkina T I, Denisenko Y K and Sidletskaya K A (2017) Changes in the surface IL-6 receptor expression of distinct immune cells in progression of chronic obstructive pulmonary disease. Medical Immunology 19(2):191???196. 2. Cosmi L, Liotta F and Annunziato F (2016) Th17 regulating lower airway disease. Current Opinion Allergy Clinical Immunology 16(1):1-6. 3. Wolf J, Rose-John S, Garbers C (2014) Interleukin-6 and its receptors: a highly regulated and dynamic system. Cytokine 70(1):11???20. 4. Ferrari R, Tanni S E, Caram L M O, Correa C, Correa C R, et al. (2013) Three-year follow-up of Interleukin 6 and C-reactive protein in chronic obstructive pulmonary disease. Respiratory Research 14(24). 5. Rincon M and Irvin C G (2012) Role of IL-6 in asthma and other inflammatory pulmonary diseases. International Journal of Biological Sciences 8(9):1281???1290 I thank the event for giving me an opportunity to speak in front of delegates and many other people from pulmonologists all over the world. I thank everyone for giving good reviews and testimonials for my talk. It was really a great experience for me to attend this two day conference and I enjoyed all the talks at the conference venue and gained lot of knowledge. I am also interested in attending more and more conference of conference series in future. I also suggest young students to attend the conferences organized by conference series to gain knowledge from the talks that speaker’s present. I met colleagues with varying levels of experience in the field of pulmonology.

卡罗丽娜Sidletskaya

阅读全文下载全文