阿富汗赫拉特省首次胃癌的组织病理学评估和患病率

17^th病理学与癌症流行病学国际会议

2018年10月8日至9日，苏格兰爱丁堡

Haroon Firooz

赫拉特大学，阿富汗

海报和接受的摘要:RRJMHS

摘要

背景:胃癌是全球癌症相关死亡的主要原因之一。许多患者在诊断时为不可手术性疾病，或切除术后复发，有治疗目的。胃癌在解剖学上分为真胃腺癌和胃食管交界腺癌，组织学上分为弥漫性和肠型。胃癌的治疗应由不同学科的专家团队进行。手术是治疗局部晚期疾病的唯一方法。化疗通常与手术联合实施。在转移性疾病中，预后较差，中位生存期约为一年。在阿富汗的赫拉特省，我第一次决定对胃癌进行研究。由于过去没有病理实验室，没有关于这种疾病的患病率和发病率的数据。我在我的癌症诊断中心收集了胃癌的数据和相关的可能原因，以便让社会了解这种危险的疾病。 Unfortunately in our country most of patients diagnose in late stages of cancer because of lack of facilities and awaraness of diagnostic methods. Objective: To evaluate the histopathologic types of gastric cancer and related risk factors in Herat city. Methods: This research is a descriptive study (based on existing data) or cross sectional study. The study population consists of 152 gastric biopsies from the patients who were suffering form gastric disorders. Endoscopically mucosal resection (biopsy) is taken by endoscopists and referred to Firooz pathology laboratory for diagnosis. The research data is from 01/01/2015 to 01/01/2017. Materials: All tissues were excised by endoscopy as mucosal resections (biopsies). The diagnosis of the tissue samples were according to histologic prepared and stained slides (H&E) after standard histotechnology. Results: In this study, 152 biopsies were assessed. 137 patients diagnosed gastric cancer, among them 95 (69.2%) were males and 42 (30.7%) females, 45.26% of cancer patients aged over 60 years old. In (71.05%) of biopsies revealed intestinal type adenocarcinoma. (11.8%) of patients the biopsies showed diffuse type carcinoma. Dysplasia were noted in (6.57%) of biopsies. Finally (2.70%) of biopsies revealed atrophic gastritis and (0.65%) of cases revealed lymphoma NHL. In 49.6% of cases the tumors had proximal location and in 50.44% of cases the tumor had distal location. Low grade adenocarcinoma were seen in 22.6% of cases, moderately differentiated were seen in 19.7% of cases and poorly differentiated were seen in 57.7% of cases. In this study 41.6% of cases revealed Helicobacter pylori in gastric mucosa. Patients who diagnosed gastric cancer did not use alcohol and Tobacco, most used meat in their daily diet. Conclusion: By considering this fact that gastric cancer is a dangerous disease specially in undeveloped countries like Afghanistan and kills many people, it is mandatory for physician to diagnose gastric cancer in onset and early stages, in order to survive patients. Acording to our study most of referring patients (57.7%) suffered from Grade III adenocarcinoma and diagnosed poorly differentiated adenocarcinoma during there first endoscopy and histopathologic examination and the mean age for gastric cancer was 57.8 therfore, it is recommended for doctors to consider abdominal discomfort and gastric disorders as a serious problem and do necessary investigative methods especially in ages above 45 years with special emphasis on early diagnosis of disease inorder to reduce and decrease the death rates.

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