药物治疗偏头痛的预防:有效减少攻击频率

联合事件4^th药物化学会议& 12^th世界大会在未来的制药公司

2019年6月27日至28日|荷兰阿姆斯特丹

拉胡尔Kumar Sarvesh辛格,Anil Kumar Saksena纳伦德拉•库马尔,Akhlaque艾哈迈德和Manoj Kumar

印度国王乔治的医科大学

海报和接受抽象:药物分析

文摘

药物预防偏头痛由一长串的药物。β-受体阻滞药、抗抑郁药、抗癫痫药、钙通道阻滞剂,普瑞巴林levetiracetam等。主要的药物使用很长一段时间和一些研究已经进行调查他们在偏头痛的预防的功效。评估的有效性知名药物和一些新的搜索去年fiveyear,原始研究的文章在MEDLINE,谷歌学者和EMBASE 2019年2月15日。我们选择随机或quasi-randomized试验的药物用于预防偏头痛。我们没有比较他们每个人单独但寻找它们的有效性。比例减少攻击频率评估。我们发现我们的41个研究包括14个研究。我们排除了动物研究、抽象,只有论文和研究缺失的数据。阿米替林被发现最有效的从60%到83%不等。丙戊酸钠钠是研究最多的药物为60%减少78%攻击频率两个月后。 Pregabalin showed 65% reduction in attack frequency after two months treatment. Levetiracetam found to be effective by 58% to 70% reduction in attack frequency. Flunarizine effectiveness ranges from 46% to 76%. Erenumab (a human monoclonal antibody which blocks calcitonin gene related receptor) also showed 50% reduction in attack frequency. Fremanezumab (quarterly administration) is moderately effective with 40% reduction in attack frequency. Reduction in attack frequency was 63% by melatonin. Omega 3 polyunsaturated fatty acids showed 66% reduction in attack frequency. We may conclude that in reducing migraine attack frequency, older drugs are more effective though newer one also seems to be promising.

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