自发的体外各种表型的转换形式的因素

17^th国际会议上病理和癌症流行病学

2018年10月扭转,苏格兰爱丁堡

Dragana成为和Dragisa Misovic

临床医疗中心,贝尔格莱德,塞尔维亚

海报和接受抽象:RRJMHS

文摘

目的:一些表型变异因子B(神奇动物)在人类血清可以被识别。我们先前已经表明,有各种表型FB的浓度和活性上的差异。也观察到,在FB表型之间血清存储一个缓慢的转化率是加速在37℃。这项工作的目的是确定转化率之间的差异不同的神奇动物表型变异。方法:107名健康人的血清样本进行调查。与免疫固定电泳用于表现型。活动的FB决心使用动能,浊度的测试神奇动物血清不足。消除和电免疫分析是用于确定FB浓度。C3组件转换被跨电泳研究。结果:在分析样品60党卫军,43 FS 3 FF和一个f1表型。 Three serum samples of each phenotype were stored at 37ºC. After 24 h, 3 and 7 days in each sample FB concentration and activity and complement alternative pathway activity were determined. During conversion it was noticed that complement activity was lost on the 7th day, while FB activity remained unchanged. Using cross-electrophoresis we found that on 7th day, C3 component was completely converted leading to the loss of complement hemolytic activity. Conclusion: Phenotype FF had the fastest conversion rate, FS phenotype slower and the slowest conversion rate had SS phenotype. The differences were most obvious on the third day of conversion. Various FB phenotypes had no influence on C3 component conversion.

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